Histone methylation in stem cell renewal and lineage commitment

Publications

Articles

• Campaner, S., Spreafico, F., Burgold, T., Doni, M., Rosato, U., Amati, B., and Testa, G.
  The methyltransferase Setd7 is dispensable for the p53-mediated DNA damage response.
  Mol. Cell 43, 2011; 681-688.
  corresponding author
• G. Testa
  The time of timing: How Polycomb proteins regulate neurogenesis
  Bioessays, 2011; 33(7):519-28.
• Boniolo, G. and Testa G.
  The Identity of Living Beings, Epigenetics, and the Modesty of Philosophy.
  Erkenntnis, 2011; DOI 10.1007/s10670-011-9308-9
  corresponding author
• C.E. Pasi, A. Dereli-Oz, S. Negrini, M. Friedli, G. Fragola, A. Lombardo, G. Van Houwe,
  L. Naldini, S. Casola, G. Testa, D. Trono, P.G. Pelicci, and T.D. Halazonetis
  Genomic instability in induced stem cells
  Cell Death and Differentiation, 2011; 18(5):745-53
• G. Testa
  Stem Cell Teathrics
  Nature 2010, 465: 1012
• G. Testa
  What to do with the Grail now that we have it? iPSCs, potentiality, and public policy.
  Cell Stem Cell, 2009 Oct 2;5(4):358-9
• F. De Santa, N. Vipin, Z. H.Yap; B. K.Tusi, T. Burgold, L. Austenaa, G.Bucci, M.Caganova, S. Notarbartolo, S. Casola, G. Testa, W. Sung, C. Wei and G. Natoli
  Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
  The EMBO Journal, '2009; 28(21):3341-52'
• G. Natoli*, G. Testa* and F. De Santa
  The future therapeutic potential of histone demethylases: a critical analysis
  Current Opinion in Drug Discovery and Development 2009; 12(5):607-15 *corresponding authors
• L. Skene, G. Testa, I. Hyun, K. W. Jung, A. McNab, J. Robertson, C. T. Scott, J. H. Solbakk, P. Taylor, L. Zoloth
  Ethics Report on Interspecies Somatic Cell Nuclear Transfer Research
  Cell Stem Cell, 2009; 5(1): 27-30
• T. Burgold, F. Spreafico, F. De Santa, M. Totaro, E. Prosperini, G. Natoli and G. Testa
  The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment
  PloS One 2008 3(8): e3034 [pdf]
• J.A. Adjaye, A.G. Byskov, J.B. Cibelli, R. De Maria, S. Minger, M. Sampaolesi, G. Testa, C. Verfaillie, M. Zernicka-Goetz, H. Schöler, M. Boiani, N. Crosetto, C.A. Redi
  Pluripotency and differentiation in embryos and stem cells
  Int J Dev Biol 2008 52(7):801-9 equal contribution
• G. Testa
  Stem cells through stem beliefs: the co-production of biotechnological pluralism
  Science as Culture 2008 17(4): 435-448
• F. De Santa, M. Totaro, E. Prosperini, S. Notarbartolo, G. Testa, and G. Natoli
  The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
  Cell 2007 130(6):1083-94.
• I. Hyun*, P. Taylor*, G. Testa*, B. Dickens, K. W. Jung, A. McNab, J. Robertson, L. Skene and L. Zoloth
  Ethical Standards for Human-to-Animal Chimera Experiments in Stem Cell Research
  Cell Stem Cell 2007 1(2):159-163 *equal contribution
• G. Testa, L. Borghese, J. Steinbeck, and O. Brüstle
  Breakdown of the Potentiality Principle and Its Impact on Global Stem Cell Research
  Cell Stem Cell 2007 1(2):153-156
• J. Scholten, K. Hartmann, A. Gerbaulet, T. Krieg, W. Müller, G. Testa, and A. Roers
  Mast cell-specific Cre/loxP-mediated recombination in vivo Transgenic Res.
  Epub 2007 Oct 31 (2008 (2):307-15)
• G. Testa
  Nuclear Transfer: an Example of Responsive Epistemologies
  Preprint 310 of the Proceedings of the Max Planck Institute for the History of Science 2006 pp. 205-214
• G. Testa and J. Harris
  Ethics and synthetic gametes
  Bioethics, 2005; 19: 146-166 [pdf]
• G. Testa and J. Harris
  Ethical aspects of ES cell-derived gametes
  Science, 2004; 305:1719 [pdf]
• G. Testa and J. Harris
  The ethics of deriving gametes from ES cells, response to A. Lippman and S.A. Newman
  Science, 2005;307: 515c-517c [pdf]
• G. Testa, J. Schaft, F.v.d. Hoeven, S. Glaser, Y. Zhang, T. Hermann, W. Stremmel and A. F. Stewart
  A reliable lacZ expression reporter cassette for multipurpose, knock-out-first, alleles
  Genesis, 2004, 38(3):151-8 [pdf ]
• G. Testa, K. Vintersten, Y. Zhang, V. Benes, J.P.P. Muyrers and A. F. Stewart
  BAC Engineering for the generation of ES cell-targeting constructs and mouse transgenes
  Methods Mol Biol. 2004; 256:141-58
• K. Vintersten, G. Testa, A. F. Stewart.
  Microinjection of BAC DNA into the pronucei of fertilised mouse oocytes
  Methods Mol Biol. 2004; 256: 141-58
• J.P.P. Muyrers, Y. Zhang, V. Benes, J.M.J. Rientjes, G. Testa and A. F. Stewart
  ET recombination: DNA engineering using homologous recombination in E. coli
  Methods Mol Biol. 2004; 256: 107-22
• G. Testa, Y. Zhang, K. Vintersten, V. Benes, I. Chambers, W. W. M. Pim Pijnappel, A. J.H. Smith, A. A. Smith and A. F. Stewart
  Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles
  Nature Biotechnology, 2003; 21(4): 443-7 [pdf]
• T. Schell, G. Testa, S. Castagnetti, B. Rutz, M. Hannus and F. Frischknecht
  Neuroscience from different angles. Student symposium: From genes to thoughts
  EMBO Reports 2001 Jun; 2(6):471-5 equal contribution [pdf]
• G. Testa and A. F. Stewart
  Creating a transloxation: engineering interchromosomal translocations in the mouse
  EMBO Reports, 2000 Aug; 1(2):120-1 [pdf]
• Y. Zhang, J. P. P. Muyrers, G. Testa and A. F. Stewart
  DNA cloning by homologous recombination in Escherichia coli.
  Nature Biotechnology 2000 Dec; 18(12):1314-7 [pdf]
• J. P. P. Muyrers, Y. Zhang, V. Benes, G. Testa, W. Ansorge and A. F. Stewart
  Point mutation of bacterial artificial chromosomes by ET recombination.
  EMBO Reports 2000 Sep; 1(3):239-43 [pdf]
• J. P. P. Muyrers, Y. Zhang, G. Testa and A. F. Stewart
  Rapid modification of bacterial artificial chromosomes by ET-recombination
  Nucleic Acid Research, 1999 Mar 15; 27(6): 1555-1557
• G. Nocentini, S. Ronchetti, A. Bartoli, G. Testa, F. D’Adamio, C. Riccardi and G. Migliorati
  TCRi: an alternatively sliced product of the T cell receptor zeta gene
  European Journal of Immunology 1995 25: 1405-1409

Books and book chapters

• G. Testa
  ´More Than Just a Nucleus: Cloning and the Alignment of Scientific and Political Rationalities´ in Sheila Jasanoff (Ed.) ´Reframing Rights: Bioconstitutionalism in the Genetic Age´,
  2011 MIT Press, pp. 86-104
  Read the endorsements here
  
• H. Nowotny and G. Testa
  Naked Genes. Reinventing the Human in the Molecular Age, 2011 MIT Press
  Originally appeared as 'Die gläsernen Gene. Die Erfindung des Individuums im molekularen Zeitalter,
  2009 Suhrkamp Verlag [cover] (Italian translations forthcoming in 2012)
  [Read the endorsements] [Read the review in the 'Financial Times' by Stephen Cave]
  [Read the review in 'Die Zeit' by Barbara Prainsack] [Read the review on Der Spiegel Online] [Read more reviews]
  
• G. Testa
  ´Cloning as Mirror´
  in Cristoph Zollikofer (Ed.) ´Klon statt Person´, 2011 Hochschulverlag AG an der ETH Zuerich, pp. 45-50
  
• G. Testa
  ´Le scienze della vita. Verso nuove antropogenesi?´
  in Antonio Pavan and Emanuela Magno (Eds.) ´Antropogenesi. Ricerche sull'origine e lo sviluppo del fenomeno umano´ 2010, Il Mulino
  
• G. Testa and S. Giaimo
  ´Il concetto di gene´ in Giovanni Boniolo e Stefano Giaimo (Eds.) ´Filosofia e Scienze della Vita. Un´analisi dei fondamenti della biologia e della biomedicina´ 2008 Bruno Mondadori
  
• G. Testa and A. Minelli
  ´Vincoli ed epigenesi´ in Giovanni Boniolo e Stefano Giaimo (Eds.) ´Filosofia e Scienze della Vita. Un´analisi dei fondamenti delal biologia e della biomedicina´ 2008 Bruno Mondadori
  
• G. Testa
  ´Che cos'è un clone? Practiche e significato delle biotecnologie rosse in un mondo globale´ in Massimiano Bucchi and Federico Neresini (Eds.) ´Cellule e Cittadini´ (Cells and citizens), 2006 Sironi Editore