Cell matrix signaling

Selected Publications

• Madsen, C.D. and Sidenius, N.
  The interaction between urokinase receptor and vitronectin in cell adhesion and signaling.
  Eur J Cell Biol 2008; 87: 617-29
• Caiolfa, V. R., Zamai, M., Malengo, G., Andolfo, A., Madsen, C. D., Gaudesi, D., Sutin, J., Digman, M., Gratton, E., Blasi, F., and Sidenius, N.
  Cell surface protein assemblies determine the location, diffusion and monomer-dimer dynamics of the GPI-anchored receptor uPAR.
  J Cell Biol 2007; 179: 1067-82.
• Madsen, C. D., Sarra Ferraris, G. M., Andolfo, A., Cunningham, O. M., and Sidenius, N.
  uPAR-dependent cell migration: Vitronectin provides the key.
  J Cell Biol 2007; 177: 927-939.
• Elia, C., Cassol, E., Sidenius, N., Blasi, B., Castagna, A., Poli, G. and Alfano, M. Inhibition of HIV Replication by Plasminogen Activator Is Dependent Upon
  Vitronectin-Mediated Cell Adhesion.
  J Leukoc Biol 2007; 82: 1212-1220.
• Selleri, C., Montuori, N., Ricci, P., Visconte, V., Carriero, M. V., Sidenius, N., Serio, B., Blasi, F., Rotoli, B., Rossi, G., and Ragno, P.
  Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization.
  Blood 2005; 105: 2198-2205.
• Cinque, P., Nebuloni, M., Santovito, M. L., Price, R. W., Gisslen, M., Hagberg, L., Bestetti, A., Vago, G., Lazzarin, A., Blasi, F., and Sidenius, N.
  The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations.
  Ann Neurol 2004; 55: 687-694.
• Sier, C. F., Nicoletti, I., Santovito, M. L., Frandsen, T., Aletti, G., Ferrari, A., Lissoni, A., Giavazzi, R., Blasi, F., and Sidenius, N.
  Metabolism of tumour-derived urokinase receptor and receptor fragments in cancer patients and xenografted mice.
  Thromb Haemost 2004; 91: 403-411.
• Cunningham, O., Andolfo, A., Santovito, M. L., Iuzzolino, L., Blasi, F., and Sidenius, N.
  Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions.
  EMBO J 2003; 22: 5994-6003.
• Sidenius, N., and Blasi, F. The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy.
  Cancer Metastasis Rev 2003; 22: 205-222.
• Sidenius, N., Andolfo, A., Fesce, R., and Blasi, F.
  Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization.
  J Biol Chem 2002; 277; 27982-27990.
• Andolfo, A., English, W. R., Resnati, M., Murphy, G., Blasi, F., and Sidenius, N.
  Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor.
  Thromb Haemost 2002; 88, 298-306.
• Alfano, M., Sidenius, N., Panzeri, B., Blasi, F., and Poli, G.
  Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication.
  PNAS 2002; 99: 8862-8867.
• Sidenius, N., Sier, C. F., Ullum, H., Pedersen, B. K., Lepri, A. C., Blasi, F., and Eugen-Olsen, J.
  Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection.
  Blood 2000; 96: 4091-4095.
• Sidenius, N., and Blasi, F.
  Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin.
  FEBS Lett 2000; 470: 40-46.