Immunobiology of Dendritic Cells and Immunotherapy

Selected publications

• Rescigno M., Urbano M., Valzasina B, Francolini M., Bonasio R.,  Kraehenbuhl JP, Granucci F, Ricciardi-Castagnoli P.
  Dendritic cells express occludin, establish junctions with gut epithelial cells and sample bacteria preserving epithelial barrier integrity.
  (2001). Nat Immunol. 2:361-367.
• Rotta G., Edwards EW, Sangaletti S., Bennett C., Ronzoni S., Colombo M.P., Steinman RM, Randolph G.J., and Rescigno M.
  Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo.
  (2003) J Exp Med. 198:1253-63.
• B. Kelsall and Rescigno M.
  Mucosal Dendritic Cells in Immunity and Inflammation
  (2004) Nat Immunol. 5:1091-1095
• Avogadri F, Martinoli C, Petrovska L, Chiodoni C, Transidico P, Colombo MP, Dougan G, Rescigno M
  Cancer immunotherapy based on killing of Salmonella-infected tumour cells
  (2005) Cancer Res.65:3920-7
• Rimoldi, M., Chieppa, M., Salucci, V., Sonzogni, A., Nespoli, A., Viale, G., Allavena, P., Rescigno, M.
  Intestinal immune homeostasis is regulated by the cross-talk between epithelial cells and dendritic cells.
  (2005) Nat Immunol. 6:507-14.
• Martinoli C, Chiavelli A, and Rescigno M.
  Entry route of Salmonella typhimurium directs the type of induced immune response.
  Immunity, 2007 Dec;27(6):975-84.
• Rotta G, Matteoli G, Mazzini E, Nuciforo P, Colombo MP, Rescigno M.
  Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity.
  J Exp Med. 2008 Mar 17;205(3):657-67. Epub 2008 Mar 3.
• Avogadri, F., Mittal, D, Saccheri, F., Sarrafiore M., Ciocca M., Larghi, P., Orecchia, R., and Rescigno M.
  Intratumoral Salmonella typhimurium induces systemic antitumor immune response that is directed by low dose radiation to treat distal disease.
  Eur. J. Immunol. 2008 Jul;38(7):1937-47.
• Cerutti A, Rescigno M.
  The biology of intestinal immunoglobulin A responses. Immunity.
  2008 Jun;28(6):740-50.
• Rescigno M, Lopatin U, Chieppa M.
  Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance.
  Curr Opin Immunol. 2008 Dec;20(6):669-75. Epub 2008 Oct 22.
• Iliev ID, Mileti E, Matteoli G, Chieppa M, Rescigno M.
  Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning.
  Mucosal Immunol. 2009 Jul;2(4):340-50. Epub 2009 Apr 22.
  (2005) Nat Immunol. 6:507-14.
• Iliev ID, Spadoni I, Mileti E, Matteoli G, Sonzogni A, Sampietro GM, Foschi D, Caprioli F, Viale G, Rescigno M.
  Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells.
  Gut. 2009 Nov;58(11):1481-9.
• Rescigno M, Di Sabatino A.
  Dendritic cells in intestinal homeostasis and disease.
  J Clin Invest. 2009 Sep;119(9):2441-50.
• Mileti E, Matteoli G, Iliev ID, Rescigno M.
  Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy.
  PLoS One. 2009 Sep 16;4(9):e7056.
• Daneman R, Rescigno M.
  The Gut Immune Barrier and the Blood-Brain Barrier: Are They So Different?
  Immunity. 2009 Nov 20;31(5):722-35.
• Matteoli G, Mazzini E, Iliev ID, Mileti E, Fallarino F, Puccetti P, Chieppa M, Rescigno M.
  Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.
  Gut. 2010 May;59(5):595-604
• Mittal D, Saccheri F, Vénéreau E, Pusterla T, Bianchi ME, Rescigno M.
  TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.
  EMBO J. 2010 Jul 7;29(13):2242-52.
• Saccheri F, Pozzi C, Avogadri F, Barozzi S, Faretta M, Fusi P, Rescigno M.
  Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity.
  Sci Transl Med. 2010 Aug 11;2(44):44ra57.
• Rescigno M.
  Intestinal dendritic cells.
  Adv Immunol. 2010;107:109-38. Review.
• Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Doré J; MetaHIT Consortium, Antolín M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Mérieux A, Melo Minardi R, M'rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P.
  Enterotypes of the human gut microbiome.
  Nature. 2011 May 12;473(7346):174-80. Epub 2011 Apr 20.
• Rescigno M.
  The intestinal epithelial barrier in the control of homeostasis and immunity.
  Trends Immunol. 2011 Jun;32(6):256-64. Epub 2011 May 11.