Regulation of protein function by monoubiquitination

Selected publications

• Polo S, Di Fiore PP.
  Finding the right partner: science or ART?
  Cell. 2008 Nov 14;135(4):590-2.
• Acconcia F, Sigismund S, Polo S.
  Ubiquitin in trafficking: The network at work.
  Exp Cell Res. 2008 Oct 28. [Epub ahead of print]
• Sigismund S, Argenzio E, Tosoni D, Cavallaro E, Polo S, Di Fiore PP.
  Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.
  Dev Cell. 2008 Aug;15(2):209-19.
• Woelk T, Sigismund S, Penengo L, Polo S.
  The ubiquitination code: a signalling problem.
  Cell Div. 2007 Mar 13;2:11.
• Woelk T, Oldrini B, Maspero E, Confalonieri S, Cavallaro E, Di Fiore PP, Polo S.
  Molecular mechanisms of coupled monoubiquitination,
  Nat Cell Biol, 8:1246-54 (2006).
• Polo S, Di Fiore PP.
  Endocytosis conducts the cell signaling orchestra.
  Cell. 2006 Mar 10;124(5):897-900
• Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR.
  Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.
  Cell. 2006 Mar 24;124(6):1183-95.
• Innocenti M, Gerboth S, Rottner K, Lai FP, Hertzog M, Stradal TE, Frittoli E, Didry D, Polo S, Disanza A, Benesch S, Di Fiore PP, Carlier MF, Scita G.
  Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.
  Nat Cell Biol. 2005 Oct;7(10):969-76.
• Mao Y, Senic-Matuglia F, Di Fiore PP, Polo S, Hodsdon ME, De Camilli P.
  Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain.
  Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12700-5. Epub 2005 Aug 23.
• Benesch S, Polo S, Lai F, Anderson K, Stradal T, Wehland J and Rottner K.
  N-WASP deficiency impairs EGF internalization and actin assembly at clathrin coated pits
  JCS, 118: 3103-15 (2005).
• Sigismund S, Woelk T, Puri C, Maspero E, Tacchetti C, Transidico P, Di Fiore PP and Polo S.
  Clathrin-independent endocytosis of ubiquitinated cargos
  Proc Natl Acad Sci U S A., 102: 2760-5 (2005).
• Sigismund S, Polo S, Di Fiore PP.
  Signaling through monoubiquitination Curr Top Microbiol
  Immunol. 286: 149-85 (2004).
• Polo S, Pece S, Di Fiore PP.
  Endocytosis and cancer Curr Opin Cell Biol. 16: 156-61 (2004).
• Polo S, Confalonieri S, Salcini AE, Di Fiore PP.
  EH and UIM: endocytosis and more Sci STKE. 213: re17 (2003).
• Chen H, Polo S, Di Fiore PP, De Camilli PV.
  Rapid Ca2+-dependent decrease of protein ubiquitination at synapses
  Proc Natl Acad Sci U S A. 100: 14908-13 (2003).
• Haglund K, Sigismund S, Polo S, Szymkiewiczi I, Di Fiore PP and Dikic I.
  Multiple monoubiquitination of receptor tyrosine kinases is sufficient for their endocytosis and degradation
  Nat Cell Biol. 5:461-6 (2003).
• Bianchi E., Denti S., Catena R., Rossetti G., Polo S., Gasparian S., Putignano S., Rogge L. and Pardi R.
  Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity
  JBC. 278:19682-90 (2003).
• Di Fiore PP, Polo S, Hofmann K.
  When Ubiquitin meets Ubiquitin Receptors: a signalling connection
  Nat. Mol. Cell Biol. Review 6:491-7 (2003).
• Polo S, Sigismund S, Faretta M, Guidi M, Capua MR, Bossi G, Chen H, De Camilli P, Di Fiore PP.
  A single motif responsible for both ubiquitin recognition and monoubiquitination in endocytic proteins.
  Nature 416:451-5 (2002).