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Molecular mechanisms of cancer and ageing

Pier Giuseppe Pelicci

[IEO]

Pier Giuseppe Pelicci
c/o IFOM-IEO Campus
Via Adamello, 16 - 20139 Milan, Italy
Tel. +39 02 57489868, Fax. +39 02 94375991
piergiuseppe.peliccimailifom-ieo-campus.it

Selected Publications (2010-2005)

  • Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP.
    Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.
    Cell. 2010 Jan 8;140(1):62-73.
  • Viale A, De Franco F, Orleth A, Cambiaghi V, Giuliani V, Bossi D, Ronchini C, Ronzoni S, Muradore I, Monestiroli S, Gobbi A, Alcalay M, Minucci S, Pelicci PG.
    Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
    Nature. 2009 Jan 1;457(7225):51-6.
  • Cicalese A, Bonizzi G, Pasi CE, Faretta M, Ronzoni S, Giulini B, Brisken C, Minucci S, Di Fiore PP, Pelicci PG.
    The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.
    Cell. 2009 Sep 18;138(6):1083-95.
  • Bonetti P, Davoli T, Sironi C, Amati B, Pelicci PG, Colombo E.
    Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma.
    J Cell Biol. 2008 Jul 14;182(1):19-26.
  • Shing DC, Trubia M, Marchesi F, Radaelli E, Belloni E, Tapinassi C, Scanziani E, Mecucci C, Crescenzi B, Lahortiga I, Odero MD, Zardo G, Gruszka A, Minucci S, Di Fiore PP, Pelicci PG.
    Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice.
    J Clin Invest. 2007 Dec;117(12):3696-707.
  • Colombo E, Martinelli P, Zamponi R, Shing DC, Bonetti P, Luzi L, Volorio S, Bernard L, Pruneri G, Alcalay M, Pelicci PG.
    Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.
    Cancer Res. 2006 Mar 15;66(6):3044-50.
  • Mariano AR, Colombo E, Luzi L, Martinelli P, Volorio S, Bernard L, Meani N, Bergomas R, Alcalay M, Pelicci PG.
    Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.
    Oncogene. 2006 Jul 20;25(31):4376-80.
  • Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, Altucci L, Nervi C, Minucci S, Pelicci PG
    Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway.
    Nat Med 11(1):71-6, 2005
  • Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG , Martelli MF
    GIMEMA Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
    N Engl J Med 20;352(3):254-66, 2005
  • Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M.
    p66Shc-generated oxidative signal promotes fat accumulation.
    J Biol Chem. 2008 Dec 5;283(49):34283-93.
  • Giorgio M, Trinei M, Migliaccio E, Pelicci PG.
    Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
    Nat Rev Mol Cell Biol. 2007 Sep;8(9):722-8.
  • Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, Pelliccia P, Luzi L, Minucci S, Marcaccio M, Pinton P, Rizzuto R, Bernardi P, Paolucci F, and Pelicci PG
    Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis.
    Cell, Vol. 122, 1-13. 2005
update: April 2010
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