Biology and signal transduction of normal and cancer neural stem cells

Selected publications

• De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM.
  RAI(ShcC/N-Shc)-dependent recruitment of GAB1 to RET oncoproteins potentiates PI3-K signalling in thyroid tumors.
  Oncogene. 2005 Jun 6.
• Troglio F, Echart C, Gobbi A, Pawson T, Pelicci PG, De Simoni MG, Pelicci G.
  From The Cover: The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia.
  Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15476-81. Epub 2004 Oct 19.
• Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG.
  The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.
  Mol Cell Biol. 2002 Oct;22(20):7351-63.
• Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L.
  Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
  J Biol Chem. 2002 May 10;277(19):16798-804.
• Conti L, Sipione S, Magrassi L, Bonfanti L, Rigamonti D, Pettirossi V, Peschanski M, Haddad B, Pelicci P, Milanesi G, Pelicci G, Cattaneo E.
  Shc signaling in differentiating neural progenitor cells.
  Nat Neurosci. 2001 Jun;4(6):579-86.
• Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG.
  The p66shc adaptor protein controls oxidative stress response and life span in mammals.
  Nature. 1999 Nov 18;402(6759):309-13.
• Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG.
  Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
  EMBO J. 1997 Feb 17;16(4):706-16.
• Pelicci G, Dente L, De Giuseppe A, Verducci-Galletti B, Giuli S, Mele S, Vetriani C, Giorgio M, Pandolfi PP, Cesareni G, Pelicci PG.
  A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.
  Oncogene. 1996 Aug 1;13(3):633-41.
• Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L, Pelicci PG.
  Not all Shc's roads lead to Ras. Trends Biochem Sci. 1996
  Jul;21(7):257-61. Review.
• Pelicci G, Lanfrancone L, Salcini AE, Romano A, Mele S, Grazia Borrello M, Segatto O, Di Fiore PP, Pelicci PG.
  Constitutive phosphorylation of Shc proteins in human tumors.
  Oncogene. 1995 Sep 7;11(5):899-907.
• Pelicci G, Giordano S, Zhen Z, Salcini AE, Lanfrancone L, Bardelli A, Panayotou G, Waterfield MD, Ponzetto C, Pelicci PG, et al.
  The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.
  Oncogene. 1995 Apr 20;10(8):1631-8.
• Lanfrancone L, Pelicci G, Brizzi MF, Aronica MG, Casciari C, Giuli S, Pegoraro L, Pawson T, Pelicci PG, Arouica MG [corrected to Aronica MG].
  Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.
  Oncogene. 1995 Mar 2;10(5):907-17.
• Salcini AE, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci PG.
  Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.
  Oncogene. 1994 Oct;9(10):2827-36.
• Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA.
  The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins.
  Oncogene. 1994 Jun;9(6):1661-8.
• Dilworth SM, Brewster CE, Jones MD, Lanfrancone L, Pelicci G, Pelicci PG.
  Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.
  Nature. 1994 Jan 6;367(6458):87-90.
• Segatto O, Pelicci G, Giuli S, Digiesi G, Di Fiore PP, McGlade J, Pawson T, Pelicci PG.
  Shc products are substrates of erbB-2 kinase.
  Oncogene. 1993 Aug;8(8):2105-12.
• Pronk GJ, McGlade J, Pelicci G, Pawson T, Bos JL.
  Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
  J Biol Chem. 1993 Mar 15;268(8):5748-53.
• Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, et al.
  Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.
  Nature. 1992 Dec 17;360(6405):689-92.
• McGlade J, Cheng A, Pelicci G, Pelicci PG, Pawson T.
  Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
  Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8869-73.
• Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG.
  A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
  Cell. 1992 Jul 10;70(1):93-104.