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Transcriptional control in inflammation and cancer



Gioacchino Natoli
c/o IFOM-IEO Campus
Via Adamello, 16 - 20139 Milan, Italy
Tel. 02 57489.953

Selected publications

  • G. Natoli, S. Ghisletti, I. Barozzi
    The genomic landscapes of inflammation
    Genes & Development 25, 101-106 (2011)
  • Natoli G.
    Maintaining Cell Identity through Global Control of Genomic Organization.
    Immunity Jul 23;33(1):12-24 (2010)
  • De Santa F, Barozzi I, Mietton F, Ghisletti S, Polletti S, Tusi BK, Muller H, Ragoussis J, Wei CL, Natoli G.
    A large fraction of extragenic RNA pol II transcription sites overlap enhancers.
    PLoS Biol. May 11;8(5):e1000384 (2010)
  • S. Ghisletti, I. Barozzi, F. Mietton, S. Polletti, F. De Santa, E. Venturini, L. Gregory, L. Lonie, A. Chew, C.L. Wei, J. Ragoussis, G. Natoli
    Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.
    Immunity Mar 26;32(3):317-28. Epub 2010 Mar 4 (2010)
  • L. Giorgetti, T. Siggers, G. Tiana, G. Caprara, S. Notarbartolo, T. Corona, M. Pasparakis, P. Milani, M. L. Bulyk, G. Natoli
    Non-cooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs.
    Molecular Cell 37, 418-428 (2010).
  • G. Natoli
    Control of NF-kappaB-dependent Transcriptional Responses by Chromatin Organization.
    Cold Spring Harbor Perspect Biol. Oct;1(4):a000224 (2009).
  • G. Natoli
    Chromatin-mediated control of gene expression in innate immunity and inflammation.
    Handbook of Cell Signalling 2nd edition (Bradshaw and Dennis eds., Academic Press) pp. 2461-2466 (2009).
  • F. De Santa, V. Narang, Z. H. Yap, B. Khoramian Tusi, T.Burgold, L. Austenaa, G. Bucci, M. Caganova, S. Notarbartolo, S. Casola, G. Testa, WK. Sung, CL. Wei, and G. Natoli
    Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.
    EMBO J. 28, 3341-52 (2009).
  • G. Natoli
    When sirtuins and NF-kB collide.
    Cell 136, 19-21 (2009).
  • van Essen D, B. Engist, G. Natoli, Saccani S
    Two modes of transcriptional activation at native promoters by NF-kappaB p65.
    PLoS Biol. 7(3):e73 (2009).
  • G. Natoli and S. Chiocca
    Nuclear ubiquitin ligases, NF-kB degradation and the control of inflammation.
    Science Signaling, January 8, pe1 (2008).
  • G. Natoli and L. Austenaa
    A birthday gift for TRADD.
    Nature Immunol. 9, 1015-106 (2008).
  • De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G
    The histone H3 Lysine 27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.
    Cell 130, 1083-1094 (2007).
  • Bosisio D, Marazzi I, Agresti A, Shimizu N, Bianchi ME, Natoli G
    A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity.
    EMBO J. 2006 Feb 22;25(4):798-810. Epub 2006 Feb 9
  • S. Sanjabi, KJ. Williams, S. Saccani, L. Zhou, A. Hoffmann, G. Ghosh, S. Gerondakis, D. Baltimore, G. Natoli and S.T. Smale
    A c-Rel subdomain responsible for enhanced DNA-binding activity and selective gene activation.
    Genes & Development 2005 19, 2138-2151.
  • G. Natoli, S. Saccani, D. Bosisio, I.
    Marazzi Interactions of NF-kB with chromatin: the art of being at the right place at the right time.
    Nature Immunol. 6, 439-445 (2005).
  • M. Covic, PO. Hassa, S. Saccani, C. Buerki, N.I. Meier, C. Lombardi, R. Imhof, M.T. Bedford, G. Natoli, MO. Hottiger
    Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kB-dependent gene expression.
    EMBO J. 24, 85-96 (2005).
  • G. Natoli
    Little things that count in transcriptional regulation.
    Cell 118, 406-408 (2004).
  • S. Saccani, I. Marazzi, G. Natoli
    Degradation of promoter-bound p65/RelA is essential for the prompt termination of the NF-kB response.
    J. Exp. Med. 200, 107-113 (2004).
  • S. Saccani, S. Pantano, G. Natoli
    Modulation of NF-kB activity by exchange of dimers.
    Molecular Cell 11, 1563-1574 (2003).
  • M. Messi, I. Giachetto, K. Nagata, A. Lanzavecchia, G. Natoli and F. Sallusto
    Memory and flexibility of cytokine gene expression as separable properties of human Th1 and Th2 lymphocytes.
    Nature Immunol. 4, 78-86 (2003).
  • S. Saccani and G. Natoli
    Dynamic changes in histone H3-Lys9 methylation occurring at tightly regulated inducible inflammatory genes.
    Genes & Development 16, 2219-2214 (2002).
  • S. Saccani, S.Pantano, G.Natoli
    p38-dependent marking of inflammatory genes for increased Nuclear Factor kappa B recruitment.
    Nature Immunol. 3, 69-75 (2002).
  • S.Saccani, S.Pantano, G. Natoli
    Two waves of Nuclear Factor kappa B recruitment to target promoters.
    J. Exp. Med. 193, 1351-1359 (2001).
  • A. Rossi*, P. Kapahi*, G. Natoli*, T. Takahashi, Y. Chen, M. Karin*, G. Santoro*
    Anti-inflammatory cyclopentenons prostaglandins are direct inhibitors of IkB kinase (IKK).
    Nature 403, 103-108 (2000) - * equal contributors
  • D. Rothwarf, E. Zandi, G. Natoli, M. Karin
    IKK gamma is an essential regulatory subunit of the IkB kinase complex.
    Nature 395, 297-300 (1998).
  • M. Muzio, G. Natoli, S. Saccani, M. Levrero, A. Mantovani
    The human Toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).
    J. Exp. Med. 187, 2097-2101 (1998).
  • G. Natoli, A. Costanzo, A. Ianni, D.J. Templeton, J.R. Woodgett, C. Balsano, M. Levrero
    Activation of SAPK/JNK by TNF-Receptor 1 through a non-cytotoxic TRAF2-dependent pathway.
    Science 275, 200-203 (1997).
update: February 2011
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