Chromatin alterations in tumorigenesis

Selected publications

• Contegno, F., Cioce, M., Pelicci, P.G. and Minucci, S.
  Targeting protein inactivation through an oligomerization chain reaction.
  Proc Natl Acad Sci U S A, 99, 1865-1869. (2002)
• Di Croce, L., Raker, V.A., Corsaro, M., Fazi, F., Fanelli, M., Faretta, M., Fuks, F., Lo Coco, F., Kouzarides, T., Nervi, C., Minucci, S. and Pelicci, P.G.
  Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.
  Science, 295, 1079-1082. (2002)
• Minucci, S., Maccarana, M., Cioce, M., De Luca, P., Gelmetti, V., Segalla, S., Di Croce, L., Giavara, S., Matteucci, C., Gobbi, A., Bianchini, A., Colombo, E., Schiavoni, I., Badaracco, G., Hu, X., Lazar, M.A., Landsberger, N., Nervi, C. and Pelicci, P.G.
  Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
  Mol Cell, 5, 811-820. (2000)
• Minucci, S., Monestiroli, S., Giavara, S., Ronzoni, S., Marchesi, F., Insinga, A., Diverio, D., Gasparini, P., Capillo, M., Colombo, E., Matteucci, C., Contegno, F., Lo-Coco, F., Scanziani, E., Gobbi, A. and Pelicci, P.G.
  PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors.
  Blood, 100, 2989-2995. (2002)
• Minucci, S., Nervi, C., Lo Coco, F. and Pelicci, P.G.
  Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
  Oncogene, 20, 3110-3115. (2001)
• Pearson, M., Carbone, R., Sebastiani, C., Cioce, M., Fagioli, M., Saito, S., Higashimoto, Y., Appella, E., Minucci, S., Pandolfi, P.P. and Pelicci, P.G.
  PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.
  Nature, 406, 207-210. (2000)
• Fanelli M, Fantozzi A, De Luca P, Caprodossi S, Matsuzawa SI, Lazar MA, Pelicci PG, Minucci S.
  The coiled-coil domain is the structural determinant for SIAH-mediated degradation of PML and other TRIM proteins by the proteasome.
  J Biol Chem. 2004 Feb 13;279(7):5374-9.
• Alessandra Insinga, Silvia Monestiroli, Simona Ronzoni, Roberta Carbone, Mark Pearson, Giancarlo Pruneri, Giuseppe Viale, Ettore Appella, PierGiuseppe Pelicci, and Saverio Minucci.
  Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.
  EMBO J. 2004 Mar 10;23(5):1144-54
• Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, Altucci L, Nervi C, Minucci S, Pelicci PG.
  Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway.
  Nat Med. 2005 Jan;11(1):71-6. Epub 2004 Dec 26. Erratum in: Nat Med. 2005 Feb;11(2):233.
• Minucci S, Pelicci PG.
  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.
  Nat Rev Cancer. 2006 Jan;6(1):38-51. Review.
• Carbone R, Botrugno OA, Ronzoni S, Insinga A, Di Croce L, Pelicci PG, Minucci S.
  Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.
  Mol Cell Biol. 2006 Feb;26(4):1288-96.