Molecular basis of asymmetric cell division

Publications

• Simonetta M., Manzoni R., Mosca R., Mapelli M., Massimiliano L., Vink M., Novak B., Musacchio A. and Ciliberto A. (2009)
  T The influence of catalysis on Mad2 activation dynamics.
  T PLoS Biology 7, 175-188.
• Lagace D.C., Benavides D.R., Kansy J.W., Mapelli M., Greengard P., Bibb J.A., Eisch A.J. (2008)
  T Cdk5 is essential for adult hippocampal neurogenesis.
  T Proc. Natl. Acad. Sci. U.S.A. 105, 18567-71.
• Mapelli M., Massimiliano L., Santaguida S. and Musacchio A. (2007)
  The Mad2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint.
  Cell 16, 730-743.
• Mapelli M. and Musacchio A. (2007)
  MAD contorsions: conformational dimerization boosts spindle checkpoint signaling.
  Curr. Opin. Struct. Biol. 17, 716-725.
• Vink M. Simonetta M., Transidico P., Ferrari K., Mapelli M., De Antoni A., Massimiliano L., Ciliberto A., Faretta M., Salmon E.D., Musacchio A. (2006)
  In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics.
  Curr Biol.16, 755-66.
• Mapelli M., Filipp F.V., Rancati G., Massimiliano L., Nezi L., Stier G., Hagan R.S., Confalonieri S., Piatti S., Sattler M., Musacchio A. (2006)
  Determinants of conformational dimerization of Mad2 and its inhibition by p31comet.
  EMBO J. 25, 1273-84.
• Penengo L., Mapelli M., Murachelli A.G., Confalonieri S., Magri L., Musacchio A., Di Fiore P.P., Polo S., Schneider T.R. (2006)
  Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.
  Cell 124, 1183-95.
• Sessa F., Mapelli M., Ciferri C., Tarricone C., Areces L.B., Schneider T.R., Stukenberg T.P. and Musacchio A. (2005)
  Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
  Mol. Cell 18, 379-91.
• De Antoni A., Pearson C.G., Cimini D., Canman J., Sala V., Nezi L., Mapelli M., Sironi L., Faretta M., Salmon E.D. and Musacchio A. (2005)
  The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.
  Curr. Biol. 15, 214-225.
• Mapelli M., Massimiliano L., Crovace C., Seeliger M.A., Tsai L.H., Meijer L. and Musacchio A. (2005)
  Mechanism of CDK5/p25 binding by CDK inhibitors.
  J. Med. Chem. 48, 671-679.
• Mapelli M., Panjikar S. and Tucker P. (2005)
  The crystal structure of the HSV-1 ssDNA binding protein suggests the structural basis for flexible, cooperative single-stranded DNA.
  J. Biol. Chem. 280, 2990-97.
• Ahn J.S., Radhakrishnan M.L., Mapelli M., Choi S., Tidor B., Cuny G.D., Musacchio A., Yeh L.A., Kosik K.S. (2005)
  Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.
  Chem Biol.12, 811-23.
• Lacy E.R., Wang Y., Post J., Nourse A., Webb W., Mapelli M., Musacchio A., Siuzdak G., Kriwacki R.W. (2005)
  Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.
  J. Mol. Biol. 349,764-73.
• Ahn J. S., Musacchio A., Mapelli M., Ni J., Scinto L., Stein R., Kosik K. S. and Yeh L. (2004)
  Development of a high throughput assay to screen for Tau phosphorylation inhibitors.
  Journal of Biomolecular Screenings 9, 122-131.
• Mapelli M. and Musacchio A. (2003)
  The structural perspective on CDK5.
  Neurosignals 12, 164-172.
• Sironi L., Mapelli M., Knapp S., De Antoni A., Jeang K.T. and Musacchio A. (2002).
  Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a safety belt binding mechanism for the spindle checkpoint.
  EMBO J. 21, 2496-2506.
• Mapelli M., Muehleisen M., van der Zandt H., Persico G. and Tucker P.A. (2000).
  The 60-residue C-terminal region of the single-stranded DNA binding protein of Herpes Simplex Virus type 1 is required for co-operative DNA binding.
  J. Virology 74, 8812-22.
• Mapelli M. and Tucker P.A. (1999).
  Crystallisation and preliminary x-ray studies on the Herpes Simplex Virus 1 single-stranded DNA binding protein.
  J. Struct. Biol. 128, 219-222.