Endocytosis, Signalling and Cancer

Selected publications

• Salcini, A.E., Confalonieri, S., Doria, M., Santolini, E., Tassi, E., Minenkova, O., Cesareni, G., Pelicci, P.G. and Di Fiore, P.P. Binding specificity and in vivo targets of the EH domain, a novel protein:protein interaction module. Genes & Development. 11: 2239-2249, 1997. [PubMed] [pdf]
• Chen, H., Fre', S., Slepnev, V.I., Capua, M.R., Takei, K., Butler, M.H., Di Fiore, P.P. and De Camilli, P. Epsin is an EH domain binding protein implicated in clathrin mediated endocytosis. Nature 394: 793-797, 1998. [PubMed]
• Scita, G., Nordstrom, J., Carbone, R., Giardina, G., Gutkind, S., Bjarnegard, M., Betsholtz, C. and Di Fiore, P.P. EPS8 and E3B1 transduce signals from Ras to Rac. Nature 401: 290-293, 1999. [PubMed]
• Lanzetti, L., Rybin, V., Malabarba, M.G., Christoforidis, S., Scita, G., Zerial, M., and Di Fiore, P.P. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature 408:374-377 2000. [PubMed]
• Polo, S., Sigismund, S., Faretta, M., Guidi, M., Capua, M.R, Bossi, G., Chen, H., De Camilli, P. and Di Fiore, P.P. A single motif responsible for both ubiquitin recognition and monoubiquitylation in endocytic proteins. Nature 416: 451-455, 2002. [PubMed]
• Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Di Fiore, P.P., Dikic I. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol. 5:461-466, 2003. [PubMed]
• Innocenti, M., Zucconi, A., Disanza, A., Frittoli, E., Areces, L., Steffen, A., Stradal, T. E. B., Di Fiore, P.P., Carlier, M.F. and Scita, G. Abi1 is essential for the formation and activation of a WAVE2 signaling complex mediating Rac-dependent actin remodeling. Nat Cell Biol. 6:319-327, 2004. [PubMed]
• Lanzetti, L., Palamidessi, A., Areces, L., Scita, G. and Di Fiore, P.P. Rab5 is a signaling GTPase involved in actin remodeling by receptor tyrosine kinases. Nature. 429:309-314, 2004. [PubMed]
• Pece, S., Serresi, M., Santolini, E., Capra, M., Hulleman, E., Galimberti, V., Zurrida, S., Maisoneuve, P., Viale, G. and Di Fiore, P.P. Loss of negative regulation of Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol. 167:215-221, 2004. [PubMed] [pdf]
• Croce, A., Cassata, G., Di Sanza, A., Gagliani, M.C., Tacchetti, C., Malabarba, M.G., Carlier, M-F., Scita, G., Baumeister, R. and Di Fiore, P.P. A novel actin barbed end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol. 6:1173-1179, 2004. [PubMed]
• Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P., Di Fiore, P.P. and Polo, S. Clathrin-independent endocytosis of ubiquitinated cargos. Proc. Natl. Acad. Sci .USA. 102:2760-2765, 2005. [PubMed] [pdf]
• Nicassio, F., Bianchi, F., Capra, M., Vecchi, M., Confalonieri, S., Bianchi, M., Pajalunga. D., Crescenzi, M., Bonapace, I.M., and Di Fiore, P.P. A cancer-specific transcriptional signature in human neoplasia. J Clin Invest. 115:3015-3025, 2005. [PubMed] [pdf]
• Tosoni, D., Puri, C., Confalonieri, S., Salcini, A.E., De Cammili, P., Tacchetti, C. and Di Fiore, P.P. TTP specifically regulates the internalization of the transferrin receptor. Cell 123:875-888, 2005. [PubMed]
• Polo, S. and Di Fiore, P.P. Endocytosis conducts the cell signaling orchestra. Cell. 124:897-900, 2006. [PubMed]
• Bianchi, F., Nuciforo, P., Vecchi, M., Bernard, L., Tizzoni, L., Marchetti, A., Buttitta, F., Felicioni, L., Nicassio, F., and Di Fiore, P.P. Survival prediction of stage I lung adenocarcinomas by expression of 10 genes. J Clin Invest. 117:3436-3444, 2007. [PubMed] [pdf]
• Colaluca I.N., Tosoni, D., Nuciforo, P., Senic-Matuglia, F., Galimberti, V. Viale, G., Pece, S. and Di Fiore P.P. Numb controls p53 tumor suppressor activity. Nature. 451:76-80. 2008. [PubMed]
• Palamidessi, A., Frittoli, E., Garre, M., Faretta, M., Mione, M., Testa, I., Diaspro, A., Lanzetti, L., Scita, G., and Di Fiore, P.P. Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell. 134:135-147, 2008. [PubMed]
• Sigismund, S., Argenzio, E., Tosoni, D., Cavallaro, E., Polo, S., and Di Fiore, P. P. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev Cell. 15: 209-219, 2008. [PubMed]
• Confalonieri S, Quarto M, Goisis G, Nuciforo P, Donzelli M, Jodice G, Pelosi G, Viale G, Pece S, Di Fiore PP. Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor. Oncogene. 2009 Aug 20;28(33):2959-68. [PubMed]
• Di Fiore PP. Endocytosis, signaling and cancer, much more than meets the eye. Preface. Mol Oncol. 2009 Aug;3(4):273-9. [PubMed]
• Westhoff B, Colaluca IN, D'Ario G, Donzelli M, Tosoni D, Volorio S, Pelosi G, Spaggiari L, Mazzarol G, Viale G, Pece S, Di Fiore PP. Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22293-8. [PubMed]
• Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell. 2010 Jan 8;140(1):62-73. [PubMed]
• Scita G, Di Fiore PP. The endocytic matrix. Nature. 2010 Jan 28;463(7280):464-73. Review. [PubMed]
• Pece S, Confalonieri S, R Romano P, Di Fiore PP. NUMB-ing down cancer by more than just a NOTCH. Biochim Biophys Acta. 2011 Jan;1815(1):26-43. Review. [PubMed]
• Bianchi F, Nicassio F, Marzi M, Belloni E, Dall'olio V, Bernard L, Pelosi G, Maisonneuve P, Veronesi G, Di Fiore PP. A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer. EMBO Mol Med. 2011 Aug;3(8):495-503. doi: 10.1002/emmm.201100154. [PubMed]
• Sigismund S, Confalonieri S, Ciliberto A, Polo S, Scita G and Di Fiore PP. Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan. Physiol Rev January 2012 92:(1) 273-366; doi:10.1152/physrev.00005.2011 [PubMed] [pdf]