New strategies for inhibiting tumor angiogenesis

Selected publications

• Maria Grazia Lampugnani, Fabrizio Orsenigo, Noemi Rudini, Luigi Maddaluno, Gwénola Boulday, Francoise Chapon, and Elisabetta Dejana
  CCM1 regulates vascular-lumen organization by inducing endothelial polarity
  J Cell Sci 2010 123: 1073-1080
• Abraham S, Yeo M, Montero-Balaguer M, Paterson H, Dejana E, Marshall CJ, Mavria G.
  VE-Cadherin-Mediated Cell-Cell Interaction Suppresses Sprouting via Signaling to MLC2 Phosphorylation.
  Curr Biol. 2009 Apr 1. [Epub ahead of print] PubMed PMID: 19345098.
• Dejana E, Tournier-Lasserve E, Weinstein BM.
  The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications.
  Dev Cell. 2009 Feb;16(2):209-21. Review. PubMed PMID: 19217423.
• Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P.
  Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
  Cell. 2009 Mar 6;136(5):839-51. Epub 2009 Feb 12. PubMed PMID: 19217150.
• Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B, Nourshargh S.
  Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A and PECAM-1.
  Blood. 2009 Feb 10. [Epub ahead of print] PubMed PMID: 19211506.
• Cera MR, Fabbri M, Molendini C, Corada M, Orsenigo F, Rehberg M, Reichel CA, Krombach F, Pardi R, Dejana E.
  JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling.
  J Cell Sci. 2009 Jan 15;122(Pt 2):268-77. PubMed PMID: 19118219.
• Gore AV, Lampugnani MG, Dye L, Dejana E, Weinstein BM.
  Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke.
  Dis Model Mech. 2008 Nov-Dec;1(4-5):275-81. Epub 2008 Oct 28. PubMed PMID: 19093037; PubMed Central PMCID: PMC2590810.
• Liebner S, Corada M, Bangsow T, Babbage J, Taddei A, Czupalla CJ, Reis M, Felici A, Wolburg H, Fruttiger M, Taketo MM, von Melchner H, Plate KH, Gerhardt H, Dejana E.
  Wnt/beta-catenin signaling controls development of the blood-brain barrier.
  J Cell Biol. 2008 Nov 3;183(3):409-17. Epub 2008 Oct 27. PubMed PMID: 18955553; PubMed Central PMCID: PMC2575783.
• Mathias François, Andrea Caprini, Brett Hosking, Fabrizio Orsenigo Dagmar Wilhelm, Catherine Browne, Karri Paavonen, Tara Karnezis, Ramin Shayan, Meredith Downes, Tara Davidson, Desmond Tutt, Kathryn S. E. Cheah, Steven A. Stacker, George E. O. Muscat, Marc G. Achen, Elisabetta Dejana & Peter Koopman
  Sox18 induces development of the lymphatic vasculature in mice
  Nature, in press *DOI Number: 10.1038/nature07391*
• Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, Potente M, Daly C, Dimmeler S, Dejana E.
  Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
  Nat Cell Biol. 2008 Aug;10(8):923-34.
• Rudini N, Felici A, Giampietro C, Lampugnani M, Corada M, Swirsding K, Garré M, Liebner S, Letarte M, ten Dijke P, Dejana E.
  VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
  EMBO J. 2008 Apr 9;27(7):993-1004. Epub 2008 Mar 13.
  PMID: 18337748 [PubMed - indexed for MEDLINE]
• Baluk P, Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, Vestweber D, Corada M, Molendini C, Dejana E, McDonald DM.
  Functionally specialized junctions between endothelial cells of lymphatic vessels.
  J Exp Med. 2007 Oct 1;204(10):2349-62. Epub 2007 Sep 10.
  PMID: 17846148 [PubMed - indexed for MEDLINE]
• Bordoni V, Alonzi T, Zanetta L, Khouri D, Conti A, Corazzari M, Bertolini F, Antoniotti P, Pisani G, Tognoli F, Dejana E, Tripodi M.
  Hepatocyte-conditioned medium sustains endothelial differentiation of human hematopoietic-endothelial progenitors.
  Hepatology. 2007 May;45(5):1218-28.
  PMID: 17464995 [PubMed - indexed for MEDLINE]
• Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana, E.
  Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.
  J Cell Biol. 2006 Aug 14;174(4):593-604. Epub 2006 Aug 7.
• Khandoga A, Kessler JS, Meissner H, Hanschen M, Corada M, Motoike T, Enders G, Dejana, E, Krombach F.
  Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration.
  Blood. 2005 Jul 15;106(2):725-33.
• Pece-Barbara N, Vera S, Kathirkamathamby K, Liebner S, Di Guglielmo GM, Dejana, E, Wrana JL, Letarte M.
  Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway.
  J Biol Chem. 2005 Jul 29;280(30):27800-8. Epub 2005 May 27.
• Corada M, Chimenti S, Cera MR, Vinci M, Salio M, Fiordaliso F, De Angelis N, Villa A, Bossi M, Staszewsky LI, Vecchi A, Parazzoli D, Motoike T, Latini R, Dejana, E.
  Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury.
  Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10634-9.
• Rossig L, Urbich C, Bruhl T, Dernbach E, Heeschen C, Chavakis E, Sasaki K, Aicher D, Diehl F, Seeger F, Potente M, Aicher A, Zanetta L, Dejana, E, Zeiher AM, Dimmeler S.
  Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells.
  J Exp Med. 2005 Jun 6;201(11):1825-35.
• Spagnuolo R, Corada M, Orsenigo F, Zanetta L, Deuschle U, Sandy P, Schneider C, Drake CJ, Breviario F, Dejana, E.
  Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis.
  Blood. 2004 Apr 15;103(8):3005-12.
• Crosby CV, Fleming PA, Argraves WS, Corada M, Zanetta L, Dejana, E, Drake CJ.
  VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly.
  Blood. 2005 Apr 1;105(7):2771-6.
• Cera MR, Del Prete A, Vecchi A, Corada M, Martin-Padura I, Motoike T, Tonetti P, Bazzoni G, Vermi W, Gentili F, Bernasconi S, Sato TN, Mantovani A, Dejana, E.
  Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice.
  J Clin Invest. 2004 Sep;114(5):729-38.
• Liebner S, Cattelino A, Gallini R, Rudini N, Iurlaro M, Piccolo S, Dejana, E.
  β-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse.
  J Cell Biol. 2004 Aug 2;166(3):359-67.
• Iurlaro M, Demontis F, Corada M, Zanetta L, Drake C, Gariboldi M, Peiro S, Cano A, Navarro P, Cattelino A, Tognin S, Marchisio PC, Dejana, E.
  VE-cadherin expression and clustering maintain low levels of survivin in endothelial cells.
  Am J Pathol. 2004 Jul;165(1):181-9.
• Dejana, E.
  Endothelial cell-cell junctions: happy together.
  Nat Rev Mol Cell Biol. 2004 Apr;5(4):261-70. Review.
• Cattelino, A., Liebner, S., Zanetti, A., Gallini, R., Balconi, G., Corsi, A., Bianco, P., Wolburg, H., Moore, R., Oreda, B., Kemler, R. & Dejana, E.
  The conditional inactivation of β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J. Cell Biol. 162, 1111-1122 (2003).
• Lampugnani, M. G., Zanetti, A., Corada, M., Takahashi, T., Balconi, G., Breviario, F., Orsenigo, F., Cattelino, A., Kemler, R., Daniel, T. O. & Dejana, E. Contact inhibition of VEGF-induced proliferation requires VE-cadherin, b-catenin and the phosphatase DEP-1/CD148. J Cell Biol. 161, 793-804 (2003).
• Lindblom, P., Gerhardt, H., Liebner, S., Abramsson, A., Enge, M., Hellstrom, M., Backstrom, G., Fredriksson, S., Landegren, U., Nystrom, H. C., Bergstrom, G., Dejana, E., Ostman, A., Lindahl, P. & Betsholtz, C. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes & Development 17, 1835-1840 (2003).
• Bazzoni, G. & Dejana, E. Keratinocyte junctions and the epidermal barrier: how to make a skin-tight dress. J. Cell Biol. 156, 947-949 (2002).
• Corada, M., Zanetta, L., Orsenigo, F., Breviario, F., Lampugnani, M. G., Bernasconi, S., Liao, F., Hicklin, D. J., Bohlen, P. & Dejana, E.
  A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability.
  Blood 100, 905-911 (2002).
• Lampugnani, M. G., Zanetti, A., Breviario, F., Balconi, G., Orsenigo, F., Corada, M., Spagnuolo, R., Betson, M., Braga, L. M. M. & Dejana, E.
  VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam.
  Mol. Biol. Cell 13, 1175-1189 (2002).
• Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E. & Resnick, N.
  VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells.
  Proc. Natl. Acad. Sci. U.S.A. 99, 9462-9467 (2002).
• Corada, M., Liao, F., Lindgren, M., Lampugnani, M. G., Breviario, F., Frank, R., Muller, W. A., Hicklin, D. J., Bohlen, P. & Dejana, E.
  Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability.
  Blood 97, 1679-1684 (2001).