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New strategies to inhibit tumor angiogenesis

Elisabetta Dejana

[IFOM]

Elisabetta Dejana, PhD
c/o IFOM-IEO Campus
Via Adamello, 16 - 20139 Milan, Italy
Tel +39 02 574303234/372 - fax +39 02 574303088
elisabetta.dejanamailifom.eu

Elisabetta Dejana is Full Professor of General Pathology at the Department of Biosciences, University of Milan.

Selected publications

  • Maddaluno L, Rudini N, Cuttano R, Bravi L, Costanza Giampietro, Corada M, Ferrarini L, Orsenigo F, Papa E, Boulday G, Tournier-Lasserve E, Chapon F, Richichi C, Retta SF, Lampugnani MG, Dejana E
    EndMT contributes to the onset and progression of cerebral cavernous malformations.
    Nature. 2013 Jun 9. doi: 10.1038/nature12207. PMID: 23748444
  • Dejana E., Vestweber D.
    The Role of VE-Cadherin in Vascular Morphogenesis and Permeability Control.
    Prog Mol Biol Transl Sci. 2013;116:119-44. PubMed PMID: 23481193.
  • Dejana E, Giampietro C.
    Vascular endothelial-cadherin and vascular stability.
    Curr Opin Hematol. 2012 May;19(3):218-23. Review. PubMed PMID: 22395663.
  • Giampietro C, Taddei A, Corada M, Sarra-Ferraris GM, Alcalay M, Cavallaro U, Orsenigo F, Lampugnani MG, Dejana E
    Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells.
    Blood. 2012 Mar 1;119(9):2159-70. Epub 2012 Jan 12. PubMed PMID: 22246030.
  • Orsenigo F, Giampietro C, Ferrari A, Corada M, Galaup A, Sigismund S, Ristagno G, Maddaluno L, Koh GY, Franco D, Kurtcuoglu V, Poulikakos D, Baluk P, McDonald D, Grazia Lampugnani M, Dejana E.
    Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo
    Nat Commun. 2012;3:1208. PubMed PMID: 23169049; PubMed Central PMCID: PMC3514492.
  • Boulday G, Rudini N, Maddaluno L, Blécon A, Arnould M, Gaudric A, Chapon F, Adams RH, Dejana E, Tournier-Lasserve E.
    Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice.
    J Exp Med. 2011 Aug 29;208(9):1835-47. Epub 2011 Aug 22. PubMed PMID: 21859843; PubMed Central PMCID: PMC3171098.
  • Cavallaro U, and Dejana E
    Adhesion molecule signalling: not always a sticky business.
    Nat Rev Mol Cell Biol. 2011 Mar;12(3):189-97. Review. PubMed PMID: 21346732.
  • Paolinelli R, Corada M, Orsenigo F and Dejana E
    The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?
    Pharmacol Res. 2011 Mar;63(3):165-71. Epub 2010 Dec 15. Review. PubMed PMID: 21167284.
  • Murakami M, Giampietro C, Giannotta M, Corada M, Torselli I, Orsenigo Fo, Cocito A, d'Ario G, Mazzarol G, Confalonieri So, Di Fiore PP and Dejana E
    Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression.
    PLoS One. 2011;6(6):e21242. Epub 2011 Jun 17. PubMed PMID: 21695058; PubMed Central PMCID: PMC3117883.
  • Dejana E, Nyqvist D.
    News from the brain: the GPR124 orphan receptor directs brain-specific angiogenesis.
    Sci Transl Med. 2010 Nov 17;2(58):58ps53. PubMed PMID: 21084718.
  • Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K, Ren B, Kerjaschki D, Autiero M, Ny A, Simons M, Dewerchin M, Schulte-Merker S, Dejana E, Alitalo K, Carmeliet P.
    Role of synectin in lymphatic development in zebrafish and frogs.
    Blood. 2010 Oct 28;116(17):3356-66. Epub 2010 Jul 14. PubMed PMID: 20631376; PubMed Central PMCID: PMC3490102.
  • Dejana E.
    The role of wnt signaling in physiological and pathological angiogenesis.
    Circ Res. 2010 Oct 15;107(8):943-52. Review. PubMed PMID: 20947863.
  • Corada M, Nyqvist D, Orsenigo F, Caprini A, Giampietro C, Taketo MM, Iruela-Arispe ML, Adams RH, Dejana E.
    The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.
    Dev Cell. 2010 Jun 15;18(6):938-49. PubMed PMID: 20627076.
  • Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E.
    CCM1 regulates vascular-lumen organization by inducing endothelial polarity.
    J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. PubMed PMID: 20332120.
  • Murakami M, Francavilla C, Torselli I, Corada M, Maddaluno L, Sica A, Matteoli G, Iliev ID, Mantovani A, Rescigno M, Cavallaro U, Dejana E.
    Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration.
    Cancer Res. 2010 Mar 1;70(5):1759-65. Epub 2010 Feb 16. PubMed PMID: 20160037.
  • Abraham S, Yeo M, Montero-Balaguer M, Paterson H, Dejana E., Marshall CJ, Mavria G.
    VE-Cadherin-Mediated Cell-Cell Interaction Suppresses Sprouting via Signaling to MLC2 Phosphorylation.
    Curr Biol. 2009 Apr 1. [Epub ahead of print] PubMed PMID: 19345098.
  • Dejana E.,Tournier-Lasserve E, Weinstein BM.
    The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications.
    Dev Cell. 2009 Feb;16(2):209-21. Review. PubMed PMID: 19217423.
  • Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P.
    Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
    Cell. 2009 Mar 6;136(5):839-51. Epub 2009 Feb 12. PubMed PMID: 19217150.
  • Cera MR, Fabbri M, Molendini C, Corada M, Orsenigo F, Rehberg M, Reichel CA, Krombach F, Pardi R, Dejana E.
    JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling.
    J Cell Sci. 2009 Jan 15;122(Pt 2):268-77. PubMed PMID: 19118219.
  • Liebner S, Corada M, Bangsow T, Babbage J, Taddei A, Czupalla CJ, Reis M, Felici A, Wolburg H, Fruttiger M, Taketo MM, von Melchner H, Plate KH, Gerhardt H, Dejana E.
    Wnt/beta-catenin signaling controls development of the blood-brain barrier.
    J Cell Biol. 2008 Nov 3;183(3):409-17. Epub 2008 Oct 27. PubMed PMID: 18955553; PubMed Central PMCID: PMC2575783.
  • Mathias François, Andrea Caprini, Brett Hosking, Fabrizio Orsenigo Dagmar Wilhelm, Catherine Browne, Karri Paavonen, Tara Karnezis, Ramin Shayan, Meredith Downes, Tara Davidson, Desmond Tutt, Kathryn S. E. Cheah, Steven A. Stacker, George E. O. Muscat, Marc G. Achen, Elisabetta Dejana & Peter Koopman
    Sox18 induces development of the lymphatic vasculature in mice
    Nature, in press *DOI Number: 10.1038/nature07391*
  • Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, Potente M, Daly C, Dimmeler S, Dejana E.
    Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
    Nat Cell Biol. 2008 Aug;10(8):923-34.
  • Rudini N, Felici A, Giampietro C, Lampugnani M, Corada M, Swirsding K, Garré M, Liebner S, Letarte M, ten Dijke P, Dejana E.
    VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
    EMBO J. 2008 Apr 9;27(7):993-1004. Epub 2008 Mar 13.
    PMID: 18337748 [PubMed - indexed for MEDLINE]
  • Baluk P, Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, Vestweber D, Corada M, Molendini C, Dejana E, McDonald DM.
    Functionally specialized junctions between endothelial cells of lymphatic vessels.
    J Exp Med. 2007 Oct 1;204(10):2349-62. Epub 2007 Sep 10.
    PMID: 17846148 [PubMed - indexed for MEDLINE]
  • Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana, E.
    Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.
    J Cell Biol. 2006 Aug 14;174(4):593-604. Epub 2006 Aug 7.
  • Corada M, Chimenti S, Cera MR, Vinci M, Salio M, Fiordaliso F, De Angelis N, Villa A, Bossi M, Staszewsky LI, Vecchi A, Parazzoli D, Motoike T, Latini R, Dejana, E.
    Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury.
    Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10634-9.
  • Cera MR, Del Prete A, Vecchi A, Corada M, Martin-Padura I, Motoike T, Tonetti P, Bazzoni G, Vermi W, Gentili F, Bernasconi S, Sato TN, Mantovani A, Dejana, E.
    Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice.
    J Clin Invest. 2004 Sep;114(5):729-38.
  • Liebner S, Cattelino A, Gallini R, Rudini N, Iurlaro M, Piccolo S, Dejana, E.
    β-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse.
    J Cell Biol. 2004 Aug 2;166(3):359-67.
  • Dejana, E.
    Endothelial cell-cell junctions: happy together.
    Nat Rev Mol Cell Biol. 2004 Apr;5(4):261-70. Review.
  • Bazzoni, G. & Dejana, E. Keratinocyte junctions and the epidermal barrier: how to make a skin-tight dress. J. Cell Biol. 156, 947-949 (2002).
update: June 2013
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