Telomeres and cellular senescence

Selected publications

• L Schneider, M Fumagalli and F d'Adda di Fagagna
  Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency
  Cell Death and Differentiation advance online publication 7 October 2011; doi: 10.1038/cdd.2011.129
• Decottignies A. and d’Adda di Fagagna F.
  Epigenetic alterations associated with cellular senescence: a barrier against tumorigenesis or a red carpet for cancer?
  Semin Cancer Biol. 2011 Sep 16
  PMID: 21946622 [PubMed - as supplied by publisher]
• Ogrunc M, d'Adda di Fagagna F.
  Never-ageing cellular senescence.
  Eur J Cancer. 2011 May 9
  PMID: 21561762 [PubMed - as supplied by publisher]
• Di Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G, dal Zuffo R, Matti V, d'Ario G, Montani E, Mercurio C, Hahn WC, Gorgoulis V, Minucci S, d'Adda di Fagagna F.
  Interplay between oncogene-induced DNA Damage Response and heterochromatin in senescence and cancer.
  Nature Cell Biology 13, 292–302 (2011)
  PMID: 21336312 [PubMed - in process]
• Fumagalli M, d'Adda di Fagagna F.
  SASPense and DDRama in cancer and ageing.
  Nat Cell Biol. 2009 Aug;11(8):921-3.
  PMID: 19648977 [PubMed - in process]
• Evan GI, d'Adda di Fagagna F.
  Cellular senescence: hot or what?
  Curr Opin Genet Dev. 2009 Feb;19(1):25-31. Epub 2009 Jan 30.
  PMID: 19181515 [PubMed - in process]
• Santoriello C, Deflorian G, Pezzimenti F, Kawakami K, Lanfrancone L, d'Adda di Fagagna F, Mione M.
  Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
  Dis Model Mech. 2009 Jan-Feb;2(1-2):56-67. Epub 2008 Dec 22.
  PMID: 19132118 [PubMed - in process]
• Di Micco R., Cicalese A., Fumagalli M., Dobreva M., Verrecchia A., Pelicci P.G. and d'Adda di Fagagna F.
  DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization
  Cell Cycle 2008 Nov 7(22):3601-3606
• d'Adda di Fagagna F.
  Living on a break: cellular senescence as a DNA-damage response
  Nature Reviews Cancer 8, 512-522 (July 2008)
• Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J.
  Chemokine signaling via the CXCR2 receptor reinforces senescence.
  Cell. 2008 Jun 13;133(6):1006-18.
  PMID: 18555777 [PubMed - in process]
• d'Adda di Fagagna F.
  Cellular senescence and cellular longevity: Nearly 50 years on and still working on it.
  Exp Cell Res. 2008 Jun 10;314(9):1907-8. Epub 2008 Apr 8. No abstract available.
  PMID: 18474280 [PubMed - in process]
• Di Micco R, Fumagalli M, d'Adda di Fagagna F.
  Breaking news: high-speed race ends in arrest - how oncogenes induce senescence.
  Trends Cell Biol. 2007 Oct 31; [Epub ahead of print]
  PMID: 17980599 [PubMed - as supplied by publisher]
• Campisi J, d'Adda di Fagagna F.
  Cellular senescence: when bad things happen to good cells.
  Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40.
  PMID: 17667954 [PubMed - in process]
• Nucifororo PG, Luise C, Capra M, Pelosi G, d'Adda di Fagagna F.
  Complex engagement of DNA-damage response pathways in human cancer and in lung tumor progression.
  Carcinogenesis. 2007 May 22; [Epub ahead of print]
  PMID: 17522062 [PubMed - as supplied by publisher]
• Francia, S., Weiss, R.W., and d'Adda di Fagagna
  Need telomere maintenance? Call 911.
  F. Cell Division, 2007; PMID: 17229321
• Di Micco R., Fumagalli M., Cicalese A., Piccinin S. Gasparini P., Luise C., Schurra C., Garre' M., Nuciforo P., Bensimon A., Maestro R., Pelicci P.G., and d'Adda di Fagagna F.
  Oncogene-induced senescence is a DNA-damage checkpoint response triggered by DNA hyper-replication.
  Nature, 2006; 444: 638-642.
• Francia S., Weiss R.S., Hande M.P., Freire R., Jackson S.P. and d'Adda di Fagagna F.
  Telomere association, telomere length regulation and telomerase activity modulation by the mammalian Rad9/Rad1/Hus1 DNA damage checkpoint complex.
  Current Biology, 2006; 16: 1551-1558.
  
• Giavara S., Kosmidou E., Hande M.P., Bianchi M.E., Morgan A., d'Adda di Fagagna F., and Jackson S.P.
  Involvement of HMGB proteins in the maintenance of genome stability.
  Current Biology, 2005; 15: 68-72.
• Von Zglinicki T., Saretzki G., Ladhoff J., d'Adda di Fagagna F., Jackson S.P.
  Human cell senescence as a DNA damage response.
  Mechanisms of Ageing and Development, 2005 Jan;126(1):111-7.
• d'Adda di Fagagna F., Teo Soo-Hwang and Jackson S.P.
  Functional links between telomeres and proteins of the DNA-damage response.
  Genes & Development 2004; 18: 1781-1799.
• d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., von Zglinicki T., Saretzki G., Carter N.P. and Jackson S.P.
  A DNA damage checkpoint-mediated response in telomere-initiated senescence.
  Nature 2003; 426: 194-8
• Weller G.R., Kysela B., Roy R., Tonkin L.M., Scanlan E., Della M., Devine S.K., Day J.P., Wilkinson A., d'Adda di Fagagna F., Devine K.M., Bowater R.P., Jeggo P.A., Jackson S.P., Doherty A.J.
  Identification of a DNA nonhomologous end-joining complex in bacteria.
  Science 2002;297:1686-9.
• d'Adda di Fagagna F., Hande M.P., Tong W-M., Roth D., Lansdorp P.M., Wang Z-Q. and Jackson S.P.
  Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.
  Current Biology 2001; 11:1192-96.
• d'Adda di Fagagna F., Hande M.P., Tong W-M., Lansdorp P.M., Wang Z-Q. and Jackson S.P.
  Functions of Poly(ADP-ribose) polymerase in telomere length control and chromosomal stability.
  Nature Genetics 1999; 23: 76-80.