Genetics and epigenetics of lymphocyte development and transformation

Selected publications

• Grazini U, Zanardi F, Citterio E, Casola S, Goding CR, McBlane F.
  The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.
  Mol Cell. 2010 Jan 29;37(2):282-93.
• Omoei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, frigeri F, Mancuso P, De Chiara A, Pinto* A, Casola S*, Simeone A*.
  Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma
  Am J Pathol. 2009 Dec;175(6):2609-17.
  * corresponding author
• De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G.
  Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.
  EMBO J. 2009 Nov 4;28(21):3341-52.
• Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T.
  LC-{gamma}2 is essential for formation and maintenance of memory B cells.
  J Exp Med. 2009 Mar 9. [Epub ahead of print]
• Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW.
  Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis.
  Immunity. 2008 Oct;29(4):615-27.
• Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U.
  Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med. 2008 Jun 9;205(6):1317-29.
  J Exp Med. 2008 Jun 9;205(6):1317-29. Epub 2008 May 19.
• Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K.
  Regulation of the germinal center response by microRNA-155.
  Science. 2007; 316(5824):604-8.
• Casola S
  Control of peripheral B-cell development
  Curr Opin Immunol. 2007 Apr;19(2):143-9.
• Casola S* and Rajewsky K.
  B cell recruitment and selection in mouse GALT germinal centres.
  Curr Top Microbiol Immunol. 2006.; 308:155-171
  * corresponding author
• Klein U, Casola S., Cattoretti G, Shen Q, Lia M, Mo T, Ludwig T, Rajewsky K and Dalla-Favera R. 2006.
  Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.
  Nat Immunol. 2006; 7(7):773-82.
• Casola S*, Cattoretti G, Uyttersprot N, Koralov SB, Segal J, Hao Z, Waisman A, Egert A, Ghitza D and Rajewsky K.
  Tracking germinal center B cells expressing germ-line immunoglobulin {gamma}1 transcripts by conditional gene targeting.
  Proc Natl Acad Sci U S A. 2006; 103(19): 7396-401.
  * corresponding author
• Novobrantseva TI, Majeau GR, Amatucci A, Kogan S, Brenner I, Casola S, Shlomchik MJ, Koteliansky V, Hochman PS and Ibraghimov A.
  Attenuated liver fibrosis in the absence of B cells.
  J Clin Invest. 2005; 115 (11):3072-82.
• Sasaki Y, Casola S., Kutok JL, Rajewsky K and Schmidt-Supprian M.
  BAFF-R-dependent and -independent roles in B cell physiology.
  J Immunol. 2004; 173(4),2245-52.
• Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S., Coyle AJ and Rajewsky K.
  IKK2-deficiency in T cells leads to defects in priming, B cell help, germinal center reactions and homeostatic expansion.
  J Immunol. 2004; 173(3),1612-19.
• Casola S.
  Conditional gene mutagenesis in B lineage cells.
  Methods Mol Biol. Humana Press 2004; 271, 91-109.
• Casola S*, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC and Rajewsky K.
  B cell receptor signal strength determines B cell fate.
  Nat Immunol. 2004; 5(3), 317-27.
  * corresponding author