Oncogenes, Chromatin and Cell Cycle Control

Selected publications

• Frank SR, Schroeder M, Fernandez P, Taubert S and Amati B.*
  Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.
  Genes Dev. 15, 2069-2082 (2001) [PubMed]
• Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N and Sicinski P.*
  Expression of cyclins E1 and E2 during mouse development and in neoplasia.
  Proc Natl Acad Sci U S A 98, 13138-13143 (2001) [PubMed]
• Deleu L, Shellard S, Alevizopoulos K, Amati B and Land H.*
  Recruitment of TRRAP required for oncogenic transformation by E1A.
  Oncogene 20, 8270-8275 (2001) [PubMed]
• Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J, Cocito A, and Amati B.*
  Genomic targets of the human c-Myc protein.
  Genes Dev. 17, 1115-1129 (2003) [PubMed]
• Frank SR, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan HM, Livingston DM and
  Amati B.*
  Myc recruits the Tip60 histone acetyltransferase complex to chromatin.
  EMBO Rep. 4, 575-580 (2003) [PubMed]
• Rascle A*, Johnston JA and Amati B.
  A deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5.
  Mol Cell Biol. 23, 4162-4173 (2003) [PubMed]
• Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z and Amati B.*
  Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.
  EMBO J. 22, 4794-4803 (2003) [PubMed]
• Grandori C*, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell D, Swisshelm K, Frank SR, Amati B, Dalla-Favera R and Monnat RJ Jr.
  Werner syndrome protein limits MYC-induced cellular senescence.
  Genes & Development 17, 1569-1574 (2003) [PubMed]
• Taubert S, Gorrini C, Frank S., Parisi T, Fuchs M, Chan HM, Livingston DM and Amati B*
  E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1.
  Mol Cell Biol. 24, 4546-4556 (2004) [PubMed]
• Amati B.*
  Myc degradation: Dancing with ubiquitin ligases.
  PNAS 101, 8843-8844 (2004) [PubMed]
• Brenner C, Deplus R, Didelot C, Loriot A, Vire E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, Pelicci PG, Amati B, Kouzarides T, de Launoit Y, Di Croce L and
  Fuks F. *
  Myc represses transcription through recruitment of DNA methyltransferase corepressor.
  EMBO Journal 24, 336-346 (2005) [PubMed]
• Guccione E, Martinato F, Finocchiaro G, Luzi L, Tizzoni L, Dall'Olio V, Zardo G, Nervi C, Loris B, Amati B.*
  Myc-binding site recognition in the human genome is determined by Chromatin context.
  Nat Cell Biol. 8, 764-770 (2006) [PubMed]
• Squatrito M, Gorrini C, Amati B.*
  Tip60 in DNA damage response and growth control: many tricks in one HAT.
  Trends Cell Biol. 16, 433-442 (2006) [PubMed]
• Amati B and Sanchez-Arèvalo Lobo VJ*
  Myc Degradation: deubiquitinating enzymes enter the dance.
  Nature Cell Biol. 9, 729-732 (2007) [PubMed]
• Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J and Amati B.*
  Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
  Nature 448, 1063-1067 (2007) [PubMed]
• Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, Lüscher B and Amati B.*
  Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.
  Nature 449, 933-937 (2007) [PubMed]
• Martinato F, Cesaroni M, Amati B* and Guccione E.*
  Analysis of Myc-induced histone modifications on target chromatin.
  PLoS ONE 3, e3650 (2008) [PubMed]
• Bonetti P, Davoli T, Sironi C, Amati B, Pelicci PG and Colombo E.*
  Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma.
  J Cell Biol 182, 19-26 (2008) [PubMed]
• De Filippis L, Ferrari D, Rota Nodari L, Amati B, Snyder E, Vescovi AL.*
  Immortalization of human neural stem cells with the c-myc mutant T58A
  PLoS ONE 3, e3310 (2008) [PubMed]
• Smith AP, Verrecchia A, Fagà G, Doni M, Martinato F, Guccione E and Amati B*
  A positive role for Myc in TGFβ-induced Snail transcription and Epithelial to Mesenchymal Transition.
  Oncogene 28, 422-430 (2009) [PubMed]
• Bua DJ, Kuo AJ, Cheung P, Liu CL, Migliori V, Espejo A, Casadio F, Bassi C, Amati B, Bedford MT, Guccione E, Gozani O.*
  Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks.
  PLoS ONE 4, e6789 (2009) [PubMed]
• Campaner S, Doni M, Hydbring P, Verrecchia A, Bianchi L, Sardella D, Schleker T, Perna D, Tronnersjö S, Murga M, Fernandez-Capetillo O, Barbacid M, Larsson LG and Amati B*
  Cdk2 suppresses cellular senescence induced by the c-myc oncogene
  Nature Cell Biol. 12, 54-59 (2010) [PubMed]
• Pistoni M, Verrecchia A, Doni M, Guccione E and Amati B*
  Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a.
  EMBO Journal 29, 1215-1224 (2010) [PubMed]
• Müller J, Samans B, van Riggelen J, Fagà G, Peh KNR, Wei CL, Müller H, Amati B, Felsher D and Eilers M.*
  TGFβ-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas.
  Cell Cycle 9, 4622-4626 (2010) [PubMed]
• Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, Amati B, de Marco A, Biffo S*
  Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.
  Cancer Cell, 19, 765-775 (2011) [PubMed]
• Campaner S, Spreafico F, Burgold T, Doni M, Rosato U, Amati B* and Testa G.*
  The methyltransferase Setd7 is dispensable for the p53-mediated DNA damage response.
  Mol Cell 43, 681-688 (2011) [PubMed]
• Perna D, Fagà G, Verrecchia A, Gorski MM, Barozzi I, Narang V, Khng J, Lim KC, Sung WK, Sanges R, Stupka E, Oskarsson T, Trumpp A, Wei CL, Müller H and Amati B.*
  Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts.
  Oncogene in press (2011) Adv. Online Publ.: Aug 22. doi: 10.1038/onc.2011.359 [PubMed]
• Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, D'Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B and
  Fernandez-Capetillo O.*
  Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.
  Nature Struct & Mol Biol. 18, 1331-1335 (2011) [Pubmed]
• Migliori V, Muller J, Phalke S, Low D, Bezzi M, Mok WC, Sahu S.K., Gunaratn J, Capasso P, Bassi C, Cecatiello V, De Marco A, Blackstock W, Kuznetsov V, Amati B, Mapelli M and Guccione E.*
  Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
  Nature Struct & Mol Biol. in press (2011)