Functional Genomics

Selected publications

• S. Licciulli, V. Cambiaghi, G. Scafetta, A. M. Gruszka and M. Alcalay
  Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation.
  Leukemia, 2010 Feb;24(2):429-37.
  
• N. Meani and M. Alcalay:
  Role of nucleophosmin in acute myeloid leukemia.
  Expert Reviews in anticancer Therapy, 2009, Sep;9(9):1283-94.
• Meani, F. Pezzimenti, G. Deflorian, M. Mione and M. Alcalay
  The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development.
  PLoS ONE, 2009, 4(1):e4273.
• A. Viale, F. De Franco, A. Orleth, V. Cambiaghi, V. Giuliani, D. Bossi, C. Ronchini, S. Ronzoni, I. Muradore, S. Monestiroli, A. Gobbi, M. Alcalay, S. Minucci and P. G. Pelicci
  Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
  Nature. 2009 January 1, 457, 51-56.
• A. Gardini, M. Cesaroni, L. Luzi, S. P. Minardi, E. Venturini, P. G. Pelicci and M. Alcalay
  AML1/ETO oncoprotein is directed to AML1 binding regions and draws E-protein HEB onto its targets.
  PLoS Genetics, 2008, Nov;4 (11).
• M. S. Carro, F. M. Spiga, M. Quarto, V. Di Ninni, S.Volorio, M. Alcalay and H. Müller
  DEK expression is controlled by E2F and deregulated in diverse tumor types.
  Cell Cycle, 2006, Jun;5(11):1202-7.
• M. Ceribelli, M. Alcalay, M. A. Viganò and R. Mantovani
  Repression of New p53 Targets Revealed by ChIP on Chip Experiments.
  Cell Cycle, 2006 May;5(10):1102-10.
• E. Colombo, P. Martinelli, R. Zamponi, D. C. Shing, P. Bonetti, L. Luzi, S. Volorio, L. Bernard, G. Pruneri, M. Alcalay, and P. G. Pelicci
  Delocalization and Destabilization of the Arf Tumor Suppressor by the Leukemia-Associated NPM Mutant.
  Cancer Res. 2006 Mar, 66, 3044-3050.
• A.R. Mariano, E. Colombo, L. Luzi, P. Martinelli, S. Volorio, L. Bernard, N. Meani, R. Bergomas, M. Alcalay and P.G. Pelicci
  Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.
  Oncogene, 2006 Jul 20;25(31):4376-80.
• N. Meani, S. P. Minardi, Silvia Licciulli, V. Gelmetti, F. Lo Coco, C. Nervi, P. G. Pelicci, H. Müller, and M. Alcalay
  Molecular Signature of Retinoic Acid Treatment in Acute Promyleocytic Leukemia.
  Oncogene, 2005 May 5;24(20):3358-68.
• M. Alcalay, E. Tiacci, R. Bergomas, B. Bigerna, E. Venturini, S. P. Minardi, N. Meani, D. Diverio, L. Bernard, L. Tizzoni, S. Volorio, L. Luzi, E. Colombo, F. Lo Coco, C. Mecucci, B. Falini and P. G. Pelicci
  Acute Myeloid Leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem cell maintenance.
  Blood. 2005 Aug 1;106(3):899-902.
• B. Falini, C. Mecucci, E. Tiacci, M. Alcalay, R. Rosati, L. Pasqualucci, R. La Starza, D. Diverio, E. Colombo, A. Santucci, B. Bigerna, R. Pacini, A. Pucciarini, A. Liso, M. Vignetti, P. Fazi, N. Meani, V. Pettirossi, G. Saglio, F. Mandelli, F. Lo-Coco, P.G. Pelicci, and M. F. Martelli, for the GIMEMA Study Group
  Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype.
  New Engl J Med 2005;352:254-266.
• M. Alcalay, N. Meani, V. Gelmetti, A. Fantozzi, M. Fagioli, A. Orleth, D. Riganelli, C. Sebastiani, E. Cappelli, C.Casciari, M.T. Sciurpi, A.R. Mariano, S.P. Minardi, L. Luzi, H. Muller, P.P. Di Fiore, G. Frosina and P.G. Pelicci
  Acute Myeloid Leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair.
  J Clin Invest, Dec 2003; 112 (11): 1751-1762.
• Guffanti, J.F. Reid, M. Alcalay and G. Simon
  The meaning of it all: web-based resources for large-scale functional annotation and visualization of DNA microarray data.
  Trends Genet 2002 Vol.18 (11): 589-592.
• M. Alcalay, A. Orleth, C. Sebastiani, N. Meani, F. Chiaradonna, C. Casciari, M. T. Sciurpi, V. Gelmetti, D. Riganelli, S. Minucci, M. Fagioli and P.G. Pelicci
  Common themes in the pathogenesis of acute myeloid leukemia.
  Oncogene 2001 Sep 10;20(40):5680-94.